In vitro degradation and biocompatibility of poly(DL-lactide-?-caprolactone) nerve guides
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چکیده
منابع مشابه
In Vitro Degradation of Borosilicate Bioactive Glass and Poly(l-lactide-co-ε-caprolactone) Composite Scaffolds
Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO₂. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a funct...
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The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2'-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37 degrees C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics...
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We assessed the rate of release of a model nucleoside (adenosine, 5%, w/w) from nine different lactide-glycolide or lactide-caprolactone polymers. The polymer discs were eluted every second day with an artificial cerebrospinal fluid at the elution rate roughly approximating the brain extracellular fluid formation rate. Adenosine in eluate samples was assayed by HPLC. Three polymers exhibited a ...
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The use of porous blocks is limited, however, because hydroxyapatite has only modest tensile strength and a low fracture toughness, leaving it susceptible to fracture or fragmentation if subjected to mechanical loading. Incorporating hydroxyapatite granules into a biocompatible polymeric matrix produces a more robust material. Judicious selection of the loading level of the HA allows for a high...
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The essence of tissue engineering is the fabrication of autologous cells or induced stem cells in naturally derived or synthetic scaffolds to form specific tissues. Polymer is thought as an appealing source of cell-seeded scaffold owing to the diversity of its physicochemical property and can be electrospun into nano-size to mimic natural structure. Poly (L-lactic acid) (PLLA) and poly (ε-capro...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research
سال: 2003
ISSN: 0021-9304,1097-4636
DOI: 10.1002/jbm.a.10157